| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10729707 | Applied Radiation and Isotopes | 2005 | 9 Pages |
Abstract
The fluorine-18 labeled dopamine transport (DAT) ligand 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT) has shown promising properties as an in vivo DAT imaging agent in human and monkey PET studies. A semi-automated synthesis has been developed to reliably produce [18F]FECNT in a 16% decay corrected yield. This method utilizes a new [18F]fluoralkylating agent and provides high purity [18F]FECNT in a formulation suitable for human use.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
![Semi-automated preparation of the dopamine transporter ligand [18F]FECNT for human PET imaging studies](/preview/png/10729707.png "First Page Preview: Semi-automated preparation of the dopamine transporter ligand [18F]FECNT for human PET imaging studies")
Authors
Ronald J. Voll, Jonathan McConathy, Michael S. Waldrep, Ronald J. Crowe, Mark M. Goodman,