Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10729728 | Applied Radiation and Isotopes | 2005 | 7 Pages |
Abstract
The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 °C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.
Keywords
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Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Corinne Planchamp, Gerd J. Beyer, Daniel O. Slosman, François Terrier, Catherine M. Pastor,