Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10729737 | Applied Radiation and Isotopes | 2005 | 6 Pages |
Abstract
An automated synthesis for the preparation of the novel hypoxic cell marker, [18F]FRP-170 3, [18F]1-[2-fluoro-1-(hydroxymethyl)ethoxy]methyl-2- nitroimidazole, was developed using an on-column basic-hydrolysis step. The 18F-labeled protected intermediate 2 was retained on a Sep-Pak Plus C18 cartridge and, in the same cartridge at room temperature, hydrolyzed by NaOH for deacetylation to give [18F]FRP-170. The elution method from the cartridge was optimized for direct injection of the crude product into an HPLC column. Thus, [18F]FRP-170 was prepared in 20-30% decay-corrected radiochemical yield within 60Â min.
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Y. Ishikawa, R. Iwata, S. Furumoto, Y. Takai,