Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10729806 | Applied Radiation and Isotopes | 2005 | 5 Pages |
Abstract
Bakuchiol, extracted from the plant Psoralea corylifolia, has been proven to have anti-tumor, cytotoxic, anti-microbial and anti-inflammatory activity. In order to study if radiolabeled bakuchiol exhibits enhanced cytotoxicity, bakuchiol was radiolabeled with 125I. In-vitro uptake studies of 125I-bakuchiol were carried out using LS-A (lymphosarcoma) and barcl-95 (radiation-induced thymic lymphoma) ascitic and solid tumor cells of murine origin. In both LS-A and barcl-95, 125I-bakuchiol showed significant uptake. Viability studies showed that the radioiodinated compound showed greater cytotoxic effect than bakuchiol.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Ketaki Bapat, G.J. Chintalwar, Usha Pandey, V.S. Thakur, H.D. Sarma, Grace Samuel, M.R.A. Pillai, S. Chattopadhyay, Meera Venkatesh,