Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10730173 | Applied Radiation and Isotopes | 2005 | 9 Pages |
Abstract
 We describe a novel thermoresponsive polymeric drug delivery system based on poly(N-isopropylacrylamide) with isotopically labellable end groups [l-tyrosinamide or diethylenetriaminepentaacetic acid (DTPA)] designed for local radiotherapy. The polymers are readily soluble in isotonic aqueous sodium chloride at room temperature and the phase separation is complete at body temperature as proved by DSC measurements. Sufficent binding capacity for radionuclides and chemical stability are demonstrated on 125I and 90Y-labelled polymers.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
M. Hrubý, V. Å ubr, J. KuÄka, J. Kozempel, O. Lebeda, A. Sikora,