Article ID Journal Published Year Pages File Type
10730493 Applied Radiation and Isotopes 2011 5 Pages PDF
Abstract
The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin.
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Related Topics
Physical Sciences and Engineering Physics and Astronomy Radiation
Preview
One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor
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