The self-diffusion behavior of polyethylene glycol in cartilageas studied by pulsed-field gradient NMR

It will be shown that at very low (<10 wt.-%) PFG concentrations, the effect of restricted polymer diffusion in cartilage is negligible. The self-diffusion coefficients (SDC) are primarily influenced by the water content and the molecular weight (MW) of the appliec. PFG. The problems encountered with PFG NMR diffusion studies using high field gradients as well as in vivo aspects of this study are discussed.