| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10736544 | Ageing Research Reviews | 2015 | 38 Pages |
Abstract
Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.
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Authors
Ekaterina N. Proshkina, Mikhail V. Shaposhnikov, Asiya F. Sadritdinova, Anna V. Kudryavtseva, Alexey A. Moskalev,