| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10736572 | Ageing Research Reviews | 2013 | 11 Pages |
Abstract
⺠The causes of tau phosphorylation in tauopathies such as Alzheimer's disease are still uncovered. ⺠Tau phosphorylation could be to the origin of Alzheimer's disease. ⺠Tau phosphatase dysfunctions might contribute to tau phosphorylation. ⺠Knowledge of the regulation modes of tau phosphatases allows to elaborate protection strategies. ⺠The most common compounds acting on each tau phosphatase are described.
Keywords
PDPKOKAPP1PP5PKBNLSSFKNFTPHFPME-1PKCPP2BGSK3PKNpKaCaMKIIAPPProtein kinase NPTPI2PP2ATPKcdk5PP2ALCMT-1PPPprotein phosphatase-2Bc-AblPhKSrc family kinaseMAPKMitogen activated protein kinasesapolipoproteinArgOkadaic acidAlzheimer's diseasenuclear localization sequencePaired helical filamentsAgecyclin-dependent kinase-5senile plaquesMARKphosphatase and tensin homolog deleted on chromosome 10phosphorylase kinasephosphoprotein phosphataseTau phosphorylationAdvanced glycation end productsneurofibrillary tanglesprotein tyrosine phosphatasesProtein phosphatase-2Aprotein phosphatase-1Protein kinase B/AktProtein kinase CcAMP-dependent protein kinasePtenglycogen synthase kinase-3
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Ludovic Martin, Xenia Latypova, Cornelia M. Wilson, Amandine Magnaudeix, Marie-Laure Perrin, Faraj Terro,