Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease

Article ID	Journal	Published Year	Pages	File Type
10736579	Ageing Research Reviews	2013	25 Pages	PDF

Abstract

âº We summarized details of 11 commonly employed transgenic mice models, including APP, tau, double-cross transgenic mice and triple- cross transgenic mice. âº One hundred and forty-six substances from 11 mouse models have been collected identified by data mining of the PubMed database from 2001 to 2011. âº Transgenic mice models played key roles in preclinical trials and can be used for developing into the mechanism of Alzheimer's disease.

Keywords

CREB NSAIDS DHT CTS PPF mCAT KKT PAC GFAP BACE1 Aβ SAM BM-MSCs EPO HDAC ABCA1 GSPE APP NMDA GLT-1 cdk5 DAPT PKC nAChRs NFTs 7,8-DHF GM-CSF Hcy N-methyl-d-aspartic acid GSK-3 CTF IVIg T2DM Cryptotanshinone VPA ATP-binding cassette transporter 1 PDTC GSIS γ-secretase inhibitors PBN sAPPα ChEIs l-3-n-Butylphthalide L-DOPS FDA IMx HNG Acetylcholine-esterase P1-derived artificial chromosome α-phenyl-N-tert-butyl nitrone L-threo-3,4-dihydroxyphenylserine γ-Secretase modulators 7,8-Dihydroxyflavone BDNF ERK1/2 S-adenosyl methionine Pomegranate juice insulin-degrading enzyme AChE Apoe apolipoprotein E Akt erythropoietin docosahexaenoic acid cAMP response element-binding IDE amyloid beta FAD Alzheimer's disease familial Alzheimer's disease Transgenic compound A long-term potentiation LTP Non-steroidal anti-inflammatory drugs DHA Dextromethorphan pyrrolidine dithiocarbamate Dihydrotestosterone Type 2 diabetes mellitus Food and Drug Administration BBB Blood–brain barrier Cerebrolysin cyclin-dependent kinase 5 Senile plaque MARK granulocyte colony-stimulating factor G-CSF Brain-derived neurotrophic factor CAST CSF cerebro-spinal fluid cholinesterase inhibitors Transgenic mice neurofibrillary tangles Homocystine histone deacetylase ETc Valproic acid Presenilin Glial fibrillary acidic protein amyloid precursor protein extracellular signal-regulated protein kinases 1 and 2 protein kinase B Protein kinase C Propentofylline Cbl clioquinol Coenzyme Q10 Calpastatin glutamate transporter-1 glycogen synthase kinase 3 nicotinic acetylcholine receptors