Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10736586 | Ageing Research Reviews | 2013 | 13 Pages |
Abstract
⺠AD pathology leads to sleep disturbances and circadian disruptions. ⺠Sleep disturbances have a negative influence on the quality of life of patients and care givers. ⺠Sleep deprivation and hypocretin increase Aβ levels and plaque deposition. ⺠Melatonin has anti-amyloidgenic properties. ⺠Important role of both melatonin and hypocretin in modulating AD pathophysiology.
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Authors
Diane Slats, Jurgen A.H.R. Claassen, Marcel M. Verbeek, Sebastiaan Overeem,