Autophagy, polyphenols and healthy ageing

Article ID	Journal	Published Year	Pages	File Type
10736590	Ageing Research Reviews	2013	16 Pages	PDF

Abstract

âº Autophagy modulation through dietary polyphenols. âº Health advantages from polyphenol consumption may be connected to autophagy. âº Effects of resveratrol on healthy ageing and the possible connection to autophagy. âº Catechin, quercetin and curcumin favour healthy ageing and induce autophagy. âº Could a polyphenol rich diet mimic the positive effect of CR on ageing via autophagy?.

Keywords

SAMP8 ERK TSC nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 PS-1 APP Autophagic vacuoles chaperone mediated autophagy ULK1 Jnk1 PINK1 m-TOR DAPK mTORC1 ATG LC3 PCD PMN htt HMGB1 VPS Bcl-xL PTEN induced putative kinase 1 AMPK PI3K piecemeal microautophagy of the nucleus TOR Regulatory associated protein of mTOR AMP unc-51-like kinase 1 CMA Bcl-2 High-mobility group protein B1 Epigallocatechingallate Sequestosome-1 Nrf2 Aβ EGCG Hsc70 NFkappaB c-Jun N-terminal protein kinase MAPK presenilin 1 ROS Adenosine Triphosphate ATP adenosine monophosphate Adenosine monophosphate activated protein kinase Autophagy amyloid beta Alzheimer's disease Huntington's disease Neurodegenerative diseases Parkinson's disease Raptor Diet Ageing FoxO phosphatase and tensin homolog phosphatidylethanolamine phosphatidylinositol-3-kinase LAMP B-cell lymphoma 2 MEK caloric restriction Vacuolar protein sorting Programmed cell death NAD nicotinamide adenine dinucleotide target of rapamycin mammalian target of rapamycin Mammalian target of rapamycin complex 1 huntingtin protein amyloid beta precursor protein mitogen-activated protein kinase death-associated protein kinase Polyphenols Pten Tuberous sclerosis complex extracellular signal-regulated kinase Reactive oxygen species