Tau protein kinases: Involvement in Alzheimer's disease

Article ID	Journal	Published Year	Pages	File Type
10736595	Ageing Research Reviews	2013	21 Pages	PDF

Abstract

âº The causes of tau phosphorylation in tauopathies like Alzheimer's disease are still uncovered. âº Tau phosphorylation could be to the origin of Alzheimer's disease. âº Tau kinases dysfunctions might contributes to tau phosphorylation. âº Knowledge of the relative importance of tau kinases allows to elaborate protection strategies against AD. âº The most common inhibitory compounds acting on each tau kinase are described.

Keywords

STK11 NMDA cdk5 GSK3 PKC NFT CREB MBD N-methyl-d-aspartic acid PKB Presenilin-1 TAO SFK LCK PSEN1 TBCA MAPKK PKN Protein kinase N TPK tetrabromocinnamic acid SAMP10 PDPK NGF AIP pKa Jnk CaMKII APP LD50 IC50 Aβ c-Abl c-Jun N-terminal kinases ERK1/2 PhK Src family kinase MAPK MAPK kinase β-Amyloid Arg cAMP response element binding Syk Alzheimer's disease CNS lethal dose 50 blood brain barrier BBB central nervous system senile plaques spleen tyrosine kinase MARK inhibitory concentration 50 nerve growth factor MAPP phosphatase and tensin homolog deleted on chromosome 10 phosphorylase kinase Tau phosphorylation neurofibrillary tangles knock-out lymphocyte-specific protein tyrosine kinase amyloid precursor protein protein kinase B Protein kinase C Pten cables mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 glycogen synthase kinase-3