| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10736608 | Ageing Research Reviews | 2013 | 9 Pages |
Abstract
⺠Intestine-specific alterations in Insulin/IGF-1 signaling can result in longer lifespan in worms and flies. ⺠Knock-down of a mitochondrial electron transport chain subunit in the intestine of worms extends lifespan. ⺠Intestine-specific up-regulation of the Drosophila PGC-1 homolog extends lifespan. ⺠In the worm, the intestine acts as a signaling center influencing the rate of aging in responding cells. ⺠Maintaining intestinal homeostasis is important for healthy aging.
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Authors
Michael Rera, Masoud J. Azizi, David W. Walker,