Article ID Journal Published Year Pages File Type
10736638 Ageing Research Reviews 2012 17 Pages PDF
Abstract
► Meta-analysis: DR typically increases lifespan by 14-45% in rats and 4-27% in mice. ► Inbred mice have shown less favorable responses to DR than non-inbred mice. ► DBA/2 males and ILSXISS strain 114: DR has weak or negative effects on lifespan. ► Wild-derived mice: Limited DR response suggests a role of laboratory breeding. ► Translation to primates may require expanding the set of well-studied rodent genotypes.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Authors
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