Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10736658 | Ageing Research Reviews | 2005 | 54 Pages |
Abstract
Thus, the HPA-axis in AD is only moderately activated, possibly due to the initial (primary) hippocampal degeneration in this condition. There are no convincing arguments to presume a causal, primary role for cortisol in the pathogenesis of AD. Although cortisol and CRH may well be causally involved in the signs and symptoms of depression, there is so far no evidence for any major irreversible damage in the human hippocampus in this disorder.
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Dick F. Swaab, Ai-Min Bao, Paul J. Lucassen,