| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10736781 | Ageing Research Reviews | 2005 | 21 Pages |
Abstract
We conclude that the DAF-12 signalling system seems to be evolutionary conserved and that NHRs in man are critical for body homeostasis and survival. Genomic variations in these NHRs or their target genes are prime candidates for the regulation of human lifespan and disease at old age.
Keywords
NHRNORIGF-1RTlxFXRVDRPXRDAFSHPPNRSF1LBDDBDCYP7A1CETPDAX1LRH1DAF-12NGFIBLongevityfarnesoid X receptorROSBasic Local Alignment Search ToolBlasttaillessDNA-Binding Domainligand binding domainRORADetoxificationsmall heterodimer partnergerm cell nuclear factorCARLipid metabolismNOTcholesterol ester transfer proteinSingle nucleotide polymorphismSNPReactive oxygen speciesconstitutive androstane receptorAndrogen Receptorinsulin receptorinsulin-like growth factor 1 receptorMineralocorticoid receptorNuclear hormone receptorsNuclear hormone receptorVitamin D receptorProgesterone receptorPregnane X receptorglucocorticoid receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
S.P. Mooijaart, B.W. Brandt, E.A. Baldal, J. Pijpe, M. Kuningas, M. Beekman, B.J. Zwaan, P.E. Slagboom, R.G.J. Westendorp, D. van Heemst,