Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10737856 | Free Radical Biology and Medicine | 2015 | 44 Pages |
Abstract
Atherosclerosis is a chronic inflammatory disease of the vascular arterial walls. A number of studies have revealed the biological and genetic bases of atherosclerosis, and over 100 genes influence atherosclerosis development. Nrf2 plays an important role in oxidative stress response and drug metabolism, but the Nrf2 signaling pathway is closely associated with atherosclerosis development. During atherosclerosis progression, Nrf2 signaling modulates many physiological and pathophysiological processes, such as lipid homeostasis regulation, foam cell formation, macrophage polarization, redox regulation and inflammation. Interestingly, Nrf2 exhibits both pro- and anti-atherogenic effects in experimental animal models. These observations make the Nrf2 pathway a promising target to prevent atherosclerosis.
Keywords
LOX-1iNOSHFDMCP-1SR-ALDLRABCA1CD36Heme oxygenase-1PDGFHUVECABCG1oxLDLVCAM-1Fpn1NLRP3NQO1LXRVLDLsequestosome 1Ferroportin 1HDLTxnrd1Nrf2CXCL4SMChuman umbilical vascular endothelial cellGSHHO-1NAD(P)H dehydrogenase, quinone 1SQSTM1LPSICAM-1keap1CDDO-Imhigh-density lipoproteinOxidized LDLROSAtherosclerosisApoeapolipoprotein EinflammationWhite adipose tissueOxidative stressThioredoxin 1High fat dietSmooth muscle cellEndothelial cellinducible nitric oxide synthasesulfiredoxin-1antioxidant response elementplatelet-derived growth factorvery low-density lipoproteinLow-density lipoproteinLDLlipopolysaccharideMacrophageLipid metabolismIntercellular adhesion molecule 1Vascular cell adhesion molecule 1KnockdownknockoutAREmonocyte chemoattractant protein-1Kelch-like ECH-associated protein 1WATliver X receptorGlutathioneReactive oxygen speciesLDL receptor
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Authors
Junsei Mimura, Ken Itoh,