Lung endothelial barrier protection by resveratrol involves inhibition of HMGB1 release and HMGB1-induced mitochondrial oxidative damage via an Nrf2-dependent mechanism

Article ID	Journal	Published Year	Pages	File Type
10737871	Free Radical Biology and Medicine	2015	53 Pages	PDF

Keywords

NQO1 RAGE SOD2 UCP2 Heme oxygenase-1 HMGB1 TLR ZO-1 BAL cox2 DAPI DAMP HO-1 AKR1B10 Nrf2 LVT FITC HVT NAD(P)H dehydrogenase quinone 1 4′, 6-diamidino-2-phenylindole Mitochondrial DNA ROS VE-cadherin Ventilator-induced lung injury damage-associated molecular pattern Toll-like receptor high-mobility group box 1 mtDNA Free radicals Resveratrol Superoxide dismutase 2 zonula occludens Nuclear factor-erythroid 2-related factor 2 antioxidant response element Keap-1 fluorescein isothiocyanate bronchoalveolar lavage ARE VILI uncoupling protein 2 Kelch-like ECH-associated protein 1 vascular endothelial cadherin Reactive oxygen species Receptor for advanced glycation end products

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Lung endothelial barrier protection by resveratrol involves inhibition of HMGB1 release and HMGB1-induced mitochondrial oxidative damage via an Nrf2-dependent mechanism

Authors

Wen-Wen Dong, Yu-Jian Liu, Zhou Lv, Yan-Fei Mao, Ying-Wei Wang, Xiao-Yan Zhu, Lai Jiang,