| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737909 | Free Radical Biology and Medicine | 2012 | 6 Pages |
Abstract
⺠Na+-K+ pump function is critical for regulation of intracellular Na+ and Ca2+. ⺠The Na+-K+ pump is inhibited by glutathionylation of its β1 subunit at Cys46. ⺠NADPH oxidase mediates inhibition of the cardiac Na+-K+ pump. ⺠Endothelial NO synthase mediates stimulation of the cardiac Na+-K+ pump. ⺠Approaches to reverse oxidative Na+-K+ pump inhibition may be cardioprotective.
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Authors
Gemma A. Figtree, Keyvan Karimi Galougahi, Chia-Chi Liu, Helge H. Rasmussen,