| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737916 | Free Radical Biology and Medicine | 2012 | 7 Pages |
Abstract
⺠Nrf2 gene deletion provides protection against atherosclerosis at a later stage. ⺠Nrf2 is activated in atherosclerotic lesions at a later stage. ⺠Nrf2 deficiency modulates macrophage gene expression in atherosclerotic plaques. ⺠Nrf2 deletion in bone marrow-derived cells is protective against atherosclerosis.
Keywords
VLDLHeme oxygenase-1BMTVCAM-1NQO1iNOSSLPIICAM-1Arginase IHO-1oxLDLNrf2chylomicronGCLMHDLApoE knockout miceNAD(P)H dehydrogenase, quinone 1SRXN1IL-6high-density lipoproteinOxidized LDLAtherosclerosisApoeapolipoprotein Einterleukin-6Chotriglycerideinducible nitric oxide synthaseNF-E2-related factor 2TNF-αMacrophage polarizationvery low density lipoproteinlow density lipoproteinLDLglutamate-cysteine ligase, modifier subunitbone marrowsecretory leukocyte protease inhibitorintercellular cell adhesion molecule 1Vascular cell adhesion molecule 1knockoutwild typeBone marrow transplantationcholesterol
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Authors
Nobuhiko Harada, Koichi Ito, Tomonori Hosoya, Junsei Mimura, Atsushi Maruyama, Noriko Noguchi, Ken-ichi Yagami, Naoki Morito, Satoru Takahashi, Jon M. Maher, Masayuki Yamamoto, Ken Itoh,