| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737919 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠Accelerated bone loss was noted in mice lacking Nrf2 after radiation. ⺠Osteoblast mineralization was decreased in Nrf2â/â osteoblasts compared to Nrf2+/+. ⺠Treatment with N-acetylcysteine (NAC) was able to rescue osteoblast mineralization. ⺠In mice lacking Nrf2, the expression of RANKL was increased after radiation. ⺠Prior NAC treatment suppressed RANKL induction in Nrf2â/â osteoblasts.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Tapasi Rana, Michelle A. Schultz, Michael L. Freeman, Swati Biswas,