Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms

► Vitamin E is the major lipid-soluble antioxidant. ► α-Tocopherol transfer protein is the only known regulator of vitamin E status. ► Oxidative stress and promoter SNPs regulate expression of the TTPA gene. ► Our findings may explain perplexing results regarding responses to vitamin E supplementation observed in clinical trials.