Article ID Journal Published Year Pages File Type
10737922 Free Radical Biology and Medicine 2012 8 Pages PDF
Abstract
► VEGF- or H2O2-induced EC migration was inhibited by overexpression of catalase or SOD. ► H2O2-induced S-glutathiolation of SERCA2b cysteine-674 and EC Ca2+ influx required Nox2. ► VEGF-induced S-glutathiolation of SERCA2b and EC Ca2+ influx required both Nox4 and Nox2. ► Nox4-derived H2O2 mediates VEGF-induced SERCA S-glutathiolation, Ca2+ influx, and EC migration.
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Preview
Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration
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