| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737930 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠The potent chemopreventive agent p-XSC selectively induces lung glutathione (GSH) levels. ⺠GSH enhancement involves induction of γ-glutamylcysteine ligase through activation of Nrf2. ⺠The GSH conjugate p-XSeSG may be the active p-XSC metabolite. ⺠p-XSeSG may represent a potent and less toxic alternative for glutathione induction.
Keywords
GCLC1,4-phenylenebis(methylene)selenocyanatecatalytic subunit of γ-glutamylcysteine ligaseNrf2−/−γ-GCLp-XSCOrganoseleniumGCLMGCLMTSGSHNrf2MEF3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazoliumFree radicalsLung cancerNuclear factor-erythroid 2-related factor 2antioxidant response elementγ-glutamylcysteine ligasemouse embryonic fibroblastsAREGlutathione
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Authors
Sans W. Emmert, Karam El-Bayoumy, Arunangshu Das, Yuan-Wan Sun, Shantu Amin, Dhimant Desai, Cesar Aliaga, John P. Jr.,