| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737938 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠Cancer is a disease associated with changes in metabolism, redox, and gene expression. ⺠The mechanisms leading to epigenetic alterations during carcinogenesis are unknown. ⺠Epigenetic disruption of cancer genes is linked to aberrant mitochondrial metabolism. ⺠Metabolic redox changes alter cofactor availability to enzymes that alter chromatin. ⺠Aberrant metabolic and redox changes cause epigenetic instability in cancer.
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Authors
Michael J. Hitchler, Frederick E. Domann,