A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: Therapeutic implications for ALS

► We identified a small molecule, CPN-9, using a novel ligand-based virtual screening. ► CPN-9 selectively protects against oxidative stress-induced cell death. ► CPN-9 is a novel Nrf2 activator. ► Postonset administration of CPN-9 to ALS-SOD1H46R mice delays disease progression. ► CPN-9 is a potent compound for the treatment of ALS.