| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737946 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠Myeloperoxidase generates oxidants (HOCl, HOSCN, HOBr) at sites of inflammation. ⺠These oxidants react very rapidly with yeast alcohol dehydrogenase (YADH). ⺠Oxidation occurs at the active-site Zn2+-Cys/His cluster of YADH. ⺠This results in loss of activity and protein Cys and in dimerization and Zn2+ release. ⺠Zn2+-Cys/His clusters are potentially major targets for peroxidase-derived oxidants.
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Authors
Naomi L. Cook, David I. Pattison, Michael J. Davies,