| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737948 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠HDAC6 is crucial for maintenance of protein homeostasis after proteasomal failure. ⺠HDAC6 regulates the up-regulation of chaperones and heme oxygenase 1 (HO-1). ⺠HDAC6 deacetylates p38 and starts the p38MAPK-Nrf-2-mediated HO-1 induction.
Keywords
HSP27Heme oxygenase-1DcfEGTAGAPDHHO-1DAPIhsp70NRF-2HspFCS2′,7′-dichlorofluorescein4′,6-diamidino-2-phenylindoleDMSOEDTAethylene glycol tetraacetic acidEthylenediaminetetraacetic acidDeacetylationDimethyl sulfoxidefetal calf serumKeap-1protein homeostasisHeat shock proteinKelch-like ECH-associated protein 1glyceraldehyde 3-phosphate dehydrogenaseUbiquitin
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Authors
Marc Kästle, Esther Woschee, Tilman Grune,