Antioxidants counteract lipopolysaccharide-triggered alterations of human colonic smooth muscle cells

Article ID	Journal	Published Year	Pages	File Type
10737949	Free Radical Biology and Medicine	2012	10 Pages	PDF

Abstract

âº Lipopolysaccharide (LPS) contributes to bacterial-related gastrointestinal motor dysfunction. âº LPS induces persistent alterations of the redox state of colonic smooth muscle cells (SMC). âº In SMC, LPS induces a switch from a contractile to a synthetic phenotype. âº Antioxidants restore normal SMC function. âº Antioxidants could be useful in the management of postinfective motor disorders of the gut.

Keywords

MMP G-actin PI-IBS TLR F-actin NAC GSH TOC LPS SMC filamentous actin globular actin N-acetylcysteine NFκB ROS α-Tocopherol Antioxidants Contractility interleukin Oxidative stress Toll-like receptor standard error Smooth muscle cells Postinfectious irritable bowel syndrome Nuclear factor-kappa B lipopolysaccharide Mitochondrial membrane potential Glutathione Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

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Antioxidants counteract lipopolysaccharide-triggered alterations of human colonic smooth muscle cells

Authors

Paola Matarrese, Chiara Petitta, Annunziata Scirocco, Barbara Ascione, Francesca Ammoscato, Giuseppe Di Natale, Emanuela Anastasi, Matteo Marconi, Piero Chirletti, Walter Malorni, Carola Severi,