Oxidative stress and metal carcinogenesis

Article ID	Journal	Published Year	Pages	File Type
10737959	Free Radical Biology and Medicine	2012	16 Pages	PDF

Abstract

âº Environmental exposures to metals are related to an increased risk of cancers. âº Reactive oxygen species might play important roles in metal-induced carcinogenesis. âº This review covers recent advances in metal-induced generation of reactive oxidants.âº This review highlights the relationship between reactive oxidants and carcinogenesis. âº The signaling proteins involved in metal-induced carcinogenesis are also addressed.

Keywords

EGF MDA c-Jun-NH2-terminal kinase DFX AP-1 8-OHdG ERK GPX GSH HIF-1 NADPH CAT CBD NF-κB ESR Jnk NFAT MAPK interleukin Chronic Beryllium Disease Desferoxamine Electron spin resonance hypoxia-inducible factor 1 epidermal growth factor Nuclear Factor of Activated T Cells antioxidant response element Growth factor Nuclear transcription factor κB malondialdehyde ARE activator protein-1 mitogen-activated protein kinase Catalase reduced glutathione extracellular signal-regulated kinase glutathione peroxidase