| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737964 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠Nox4 is expressed predominantly in cycling hypoxic areas within the solid tumor. ⺠Tumor cycling hypoxia enhances Nox4 expression. ⺠Tumor cycling hypoxia increases reactive oxygen species levels via Nox4. ⺠Nox4 plays a critical role in cycling hypoxia-induced radioresistance. ⺠Nox4 blockage enhances the efficiency of radiotherapy in GBM xenografts.
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Authors
Chia-Hung Hsieh, Chung-Pu Wu, Hsu-Tung Lee, Ji-An Liang, Chun-Yen Yu, Yu-Jung Lin,