| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737965 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠Quercetin modulates hematological changes under hypobaric hypoxia. ⺠It reduces oxidative stress and inflammation by blocking NFκB, thereby preventing HACE. ⺠Quercetin was found to be a more potent drug than dexamethasone against HACE. ⺠Quercetin at 50 mg/kg body wt could completely remove cerebral edema in rats.
Keywords
PLTAMSPBSTHRPGPXGSHPVSDTTVRSRFUHCTMgCl2MCHCMCVHEPESMDACPCSEAKClRBCHAPEDTNBEMSADCFH-DARed blood cells4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidDMSODNANFκBROSW/DElectrophoretic mobility shift assayHACEHigh altitude pulmonary edemaHigh altitude cerebral edemadeoxyribonucleic acidinflammationstandard deviationAcute mountain sicknesshematological changesOxidative stresslethal dosedichlorofluorescein diacetatedithiothreitolDimethyl sulfoxidePCsSODSuperoxide dismutasenuclear factor kappa betaPerivascular spacemalondialdehydemean cell volumeMean corpuscular hemoglobin concentrationmillimolarhematocritHemoglobinrelative fluorescence unitWeightHorseradish peroxidasePlateletsreduced glutathioneMagnesium chloridePotassium chlorideglutathione peroxidaseReactive oxygen species
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Authors
Himadri Patir, Sarada S.K.S, Saumya Singh, Titto Mathew, Bhagwat Singh, Anju Bansal,