| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737966 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Green perilla extract exhibited high Nrf2-ARE activity. ⺠We isolated an active fraction through bioactivity-guided fractionation. ⺠The active component was 2â²,3â²-dihydroxy-4â²,6â²-dimethoxychalcone (DDC). ⺠DDC induced the expression of antioxidant enzymes. ⺠DDC provided protection against 6-hydroxydopamine-induced cytotoxicity.
Keywords
HO-1trifluoroacetic acid.Nrf2-ARE pathwayNQO1Heme oxygenase-1TFA6-HydroxydopamineGSHNrf2DcfORACPI3K6-OHDAnuclear magnetic resonance2′,7′-dichlorodihydrofluorescein diacetate2′,7′-dichlorofluorescein3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidekeap1ddCDMSOH2DCFDAMAPKMTTSmall interfering RNAROSsiRNAEthidiumethElectron impactNMROxidative stressdihydroethidiumDimethyl sulfoxideMass spectrometryoxygen radical absorbance capacityantioxidant response elementnuclear factor erythroid 2-related factor 2phosphoinositide 3-kinaseAREDHEKelch-like ECH-associated protein 1mitogen-activated protein kinaseChalconereduced glutathionehigh-pressure liquid chromatographyHPLCReactive oxygen species
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Authors
Yasuhiko Izumi, Atsuko Matsumura, Seiko Wakita, Ken-ichi Akagi, Hiroyuki Fukuda, Toshiaki Kume, Kazuhiro Irie, Yuki Takada-Takatori, Hachiro Sugimoto, Tadashi Hashimoto, Akinori Akaike,