| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737967 | Free Radical Biology and Medicine | 2012 | 10 Pages |
Abstract
⺠Therapeutic doses of Cimicifuga racemosa reduced blood pressure of hypertensive rats. ⺠C. racemosa impaired mitochondrial β-oxidation and increased reactive oxygen species generation. ⺠In addition, peroxisomal β-oxidation and catalase activity were reduced. ⺠Glutathione content was unaffected, reflecting the restoration of G6PD activity. ⺠Oxidative damage was evidenced by the elevated levels of TBARS of treated animals.
Keywords
TBARSMDA2K1CovariectomizedDNPOVXDCFH-DAOPTRASFFAGSHNADPHG6PDCATDcf2′,7′-dichlorofluorescein2′,7′-dichlorofluorescein diacetate2,4-DinitrophenolAUCGSH-Pxo-PhthalaldehydeCimicifuga racemosaROSHomeostasis model assessmentFree fatty acidOvariectomyFatty acid oxidationOxidative stressSODSuperoxide dismutaseRenin–angiotensin systemmean arterial pressuremalondialdehydearea under the curvethiobarbituric acid-reactive substancesmapHOMARenovascular hypertensionCatalasereduced glutathioneglutathione reductaseglutathione peroxidaseglucose-6-phosphate dehydrogenaseReactive oxygen species
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Authors
Lilian Brites Campos, Eduardo Hideo Gilglioni, Rosângela Fernandes Garcia, Márcia do Nascimento Brito, Maria Raquel Marçal Natali, Emy Luiza Ishii-Iwamoto, Clairce Luzia Salgueiro-Pagadigorria,