| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737968 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Adipocyte differentiation reduces Nrf2/Keap1 pathway activity. ⺠There are discrepancies between mRNA and protein changes for NQO1. ⺠Sulforaphane treatment blunted both adipocyte differentiation and hypertrophy. ⺠Effects of sulforaphane were partially mediated by NQO1 activity.
Keywords
bHLHGSTNADPHNrf2PPARγDTTSFNHBSSFABP4GSK-3βFBSDMEMIBMXNQO1PBSmiRNA regulationNAD(P)H:quinine oxidoreductase 1keap1C/EBPROSAdipogenesisbasic helix-loop-helixisobutylmethylxanthineOxidative stressRoom temperatureDexamethasonedithiothreitolfetal bovine serumSulforaphaneInsulin signalingbody mass indexBMInuclear factor E2-related factor 2antioxidant response elementelectrophile response elementPhosphate-buffered salineHank's balanced salt solutionObesityMACnicotinamide adenine dinucleotide phosphateARECCAAT/enhancer-binding proteinfatty acid binding protein 4Kelch-like ECH-associated protein 1Glycogen synthase kinase-3βreactive oxygen species.peroxisome proliferator-activated receptor γ
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Authors
Emilie E. Vomhof-DeKrey, Matthew J. Picklo,