| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737971 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠We studied the effects of GW0742 on endothelial function in type 1 diabetic rats. ⺠PPARβ/δ activation restored endothelial function in streptozotocin-induces diabetes. ⺠This drug increased nitric oxide bioavailability by downregulating NADPH oxidase. ⺠It also inhibited prepro endothelin-1 up-regulation induced by high glucose.
Keywords
ppET-1PDK4STZEDHFeNOSNG-nitro-l-arginine methyl esterSBPCPT-1VCAM-1DAPIMCP-1MPOl-NAMEO2−PPARsPPARβ/δROSAChEndothelial dysfunctionstreptozotocinAcetylcholineendothelial NO synthaseNADPH oxidasedihydroethidiumSODSuperoxideSuperoxide dismutaseShrHeart rateEndothelium-derived hyperpolarizing factorsystolic blood pressureDiabetic ratSpontaneously hypertensive ratsmyeloperoxidaseNitric oxideDHEmonocyte chemoattractant protein-1Pyruvate dehydrogenase kinase 4Carnitine palmitoyltransferase 1Reactive oxygen speciesPeroxisome proliferator-activated receptors
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Authors
Ana MarÃa Quintela, Rosario Jiménez, Manuel Gómez-Guzmán, MarÃa José Zarzuelo, Pilar Galindo, Manuel Sánchez, Félix Vargas, Ángel Cogolludo, Juan Tamargo, Francisco Pérez-VizcaÃno, Juan Duarte,