| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737972 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Silencing KEAP1 in NSCLC cells results in sensitization to chemotherapeutic agents. ⺠Knockdown of KEAP1 augments expression of PPARγ and cell differentiation-related genes. ⺠Deficiency of KEAP1 leads to elevated induction of PPARγ in response to As2O3. ⺠PPARγ agonists augment As2O3-induced cytotoxicity in NSCLC cells. ⺠NRF2 and KEAP1 are involved in the regulation of PPARγ expression.
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Authors
Lijuan Zhan, Hao Zhang, Qiang Zhang, Courtney G. Woods, Yanyan Chen, Peng Xue, Jian Dong, Erik J. Tokar, Yuanyuan Xu, Yongyong Hou, Jingqi Fu, Kathy Yarborough, Aiping Wang, Weidong Qu, Michael P. Waalkes, Melvin E. Andersen, Jingbo Pi,