| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737974 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠Renal proximal tubule cell (PTC) lysosomes of Hp 2-2 DM mice have iron deposits. ⺠Renal PTC lysosomal membranes of Hp 2-2 DM mice are oxidized. ⺠PTC lysosomal membrane integrity of Hp 2-2 DM mice is compromised. ⺠Vitamin E stabilizes PTC lysosomal membrane integrity in Hp 2-2 DM mice. ⺠Iron-induced injury may explain increased nephropathy in Hp 2-2 DM humans.
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Authors
Rabea Asleh, Farid M. Nakhoul, Rachel Miller-Lotan, Hoda Awad, Dan Farbstein, Nina S. Levy, Nakhoul Nakhoul, Theodore C. Iancu, Irena Manov, Michael Laue, Maret G. Traber, Katie M. Lebold, Andrew P. Levy,