| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737976 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Palmitate but not oleate induces a proatherogenic increase in CD11b and CD36 expression in monocytes. ⺠Elevated CD11b in palmitate-treated monocytes associates with increased adhesion to endothelial bifurcations. ⺠Increased CD36 expression promotes the uptake of oxidized LDL in palmitate-treated monocytes. ⺠Mitochondrial reactive oxygen species (ROS), intracellular C16 ceramide, and sphingomyelin are increased by palmitate but not oleate. ⺠Inhibition of de novo ceramide synthesis but not ROS mitigated the phenotypic changes in monocytes induced by palmitate.
Keywords
PBSPPMPMnTBAPBCECF-AM3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium FB1ICAM-1FFABSADiILC–MSMTTbovine serum albuminFatty acidFree fatty acidOleatecardiovascular diseaseCVDpalmitateliquid chromatography–mass spectrometryMAPPFumonisin B1Low-density lipoproteinLDLPhosphate-buffered salineintercellular adhesion molecule-1Propidium iodide
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Authors
Dan Gao, Chathyan Pararasa, Christopher R. Dunston, Clifford J. Bailey, Helen R. Griffiths,