| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737979 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠We establish a reliable assay for testing the necessity of sensor cysteines of Keap1. ⺠We identify a subset of Nrf2 inducers that require Keap1 Cys151. ⺠Keap1 utilizes distinct sets of cysteines for sensing different chemicals. ⺠This study substantiates the multiple sensing mechanism of Keap1.
Keywords
DMFtert-butylhydroquinoneOA-NO2GCLCHprtNQO115d-PGJ2BTBCDNBSFNDemReactive cysteineNrf2MEFTBHQ1-chloro-2,4-dinitrobenzenekeap1CDDO-ImMϕNAD(P)H:quinone oxidoreductase 1nitro-oleic acidDiethylmaleatedimethylfumarateSulforaphanenuclear factor erythroid 2-related factor 2Macrophagemouse embryonic fibroblasthypoxanthine guanine phosphoribosyl transferaseStress responseKelch-like ECH-associated protein 1glutamate-cysteine ligase catalytic subunit
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Authors
Kai Takaya, Takafumi Suzuki, Hozumi Motohashi, Ko Onodera, Susumu Satomi, Thomas W. Kensler, Masayuki Yamamoto,