| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737982 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠We studied RNA oxidation catalyzed by either Fe(II)/ascorbate/H2O2 or cyt c/H2O2. ⺠We found that multiple oxidation markers are essential to assess RNA oxidation. ⺠RNA forms cross-linked complexes with cyt c during cyt c-catalyzed oxidation. ⺠Cyt c release from cardiolipin-containing liposomes is facilitated by RNA-cyt c cross-linking.
Keywords
CBBtrifluoroacetic acid.RNA oxidation8-OH-Gua8-hydroxyguanineCyt CTFAARP8-hydroxydeoxyguanosineCoomassie Brilliant BlueGC/MSLC/MSROSEDTAEthylenediaminetetraacetic acidCytochrome c releaseFree radicalsabasic sitecytochrome cliquid chromatography–mass spectrometrygas chromatography–mass spectrometryphosphatidylcholineCross-link8-hydroxyguanosineCardiolipinhigh-performance liquid chromatographyHPLCReactive oxygen species
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Authors
Mikiei Tanaka, Pawel Jaruga, Pascal A. Küpfer, Christian J. Leumann, Miral Dizdaroglu, William E. Sonntag, P. Boon Chock,