| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737985 | Free Radical Biology and Medicine | 2012 | 14 Pages |
Abstract
⺠Replacement of bis-allylic H atoms with deuterium (D) arrests autoxidation of PUFA. ⺠Linoleic acid with just one bis-allylic D replacement also resists autoxidation. ⺠Linoleic acid with D at other sites (e.g. mono-allylic) remains susceptible. ⺠20 mol % of deuterated PUFA profoundly inhibits the autoxidation of other PUFA. ⺠It may be feasible to build up necessary therapeutic levels of D-PUFA in vivo.
Keywords
EPAKODEMeOAMVNPPh3YPdEtOAcOLEBHTubiquinoneQH2GC–MSHODEROSEthylacetateIsotope effectKinetic isotope effectPolyunsaturated fatty acidPUFALipid autoxidationTriphenylphosphineOxidative stressARAdeuteriumgas chromatography–mass spectrometryLinbutylated hydroxytolueneChain reactionCoenzyme QKIEReactive oxygen species
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Authors
Shauna Hill, Connor R. Lamberson, Libin Xu, Randy To, Hui S. Tsui, Vadim V. Shmanai, Andrei V. Bekish, Agape M. Awad, Beth N. Marbois, Charles R. Cantor, Ned A. Porter, Catherine F. Clarke, Mikhail S. Shchepinov,