| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737991 | Free Radical Biology and Medicine | 2012 | 15 Pages |
Abstract
⺠Upon 6-OHDA treatment, DJ-1 is translocated into the nucleus in dopaminergic cells. ⺠Antioxidant inhibits the 6-OHDA-mediated nuclear translocation of DJ-1. ⺠Ectopic expression of DJ-1 prevents 6-OHDA-induced cell death. ⺠Upon 6-OHDA treatment, localization and binding of DJ-1 to PML bodies increased. ⺠Overexpressed DJ-1 causes decreased expression of PUMA upon 6-OHDA treatment.
Keywords
6-OHDACBPNLSN-acetyl-l-cysteineDAergicPMLHDAC6-HydroxydopamineNACCM-H2DCFDASTS5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate acetyl esterNuRDTSAROSstaurosporineNucleosome Remodeling and DeacetylaseParkinson diseaseTrichostatin ADopamineDopaminergicFree radicalsnuclear localization signalDopaminergic neurodegenerationPromyelocytic leukemiawild typeNicotinamidehistone deacetylaseCREB binding proteinReactive oxygen species
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Authors
Su-Jeong Kim, Yun-Jong Park, Ih-Yeon Hwang, Moussa B.H. Youdim, Kang-Sik Park, Young J. Oh,