| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737992 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠DFO robustly inhibits tyrosine nitration (3-NT) independent of Fe chelation. ⺠The mechanism likely involves tyrosyl radical repair preventing NO2 addition. ⺠More facile reactants scavenge NO2 but lose 3-NT inhibition due to consumption. ⺠DFO effectively inhibits 3-NT in both aqueous and hydrophobic compartments. ⺠DFO multifunctionalities should be considered during its reagent and clinical use.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Margaret A. Adgent, Giuseppe L. Squadrito, Carol A. Ballinger, David M. Krzywanski, Jack R. Jr., Edward M. Postlethwait,