| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10737994 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠S-glutathionylation of complex I is a redox modification induced by oxidant stress. ⺠A protein thiyl radical intermediate is proposed to mediate S-glutathionylation. ⺠The mechanism of S-glutathionylation strictly depends on oxidant stress and glutathione. ⺠The mechanism explains the physiological relevance of S-glutathionylation.
Keywords
GSH5,5-dimethylpyrroline N-oxideubiquinone-1S-glutathionylationFMNPBSDMPOMS/MSO2•−SDS–PAGESDS–polyacrylamide gel electrophoresisEPRElectron paramagnetic resonanceSMPSubmitochondrial particleFree radicalsSuperoxide anion radicalelectron transport chainMass spectrometryTandem mass spectrometryflavin mononucleotideComplex IPhosphate-buffered salinemyocytesETcAntibodyGlutathioneImmuno-spin trapping
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Authors
Patrick T. Kang, Liwen Zhang, Chwen-Lih Chen, Jingfeng Chen, Kari B. Green, Yeong-Renn Chen,