Aldosterone, oxidative stress, and NF-κB activation in hypertension-related cardiovascular and renal diseases

► Aldosterone regulates blood pressure via genomic manipulation of extracellular volume. ► Increased aldosterone plasma levels in hypertension cause cardiovascular complications. ► Nonclassical effects by aldosterone include activation of NADPH oxidase and NOS. ► Aldosterone-induced reactive oxygen and nitrogen species activate NF-κB. ► Mechanism of damaging effects of aldosterone is not fully understood.