| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738040 | Free Radical Biology and Medicine | 2012 | 14 Pages |
Abstract
⺠Acetyl-l-carnitine attenuated ADMA-mediated proteasomal degradation of GTP cyclohydrolase I (GCH1). ⺠This prevented the decrease in BH4 levels. ⺠Treatment of Shunt lambs with l-carnitine also reduced the degradation of GCH1. ⺠This increased the BH4 levels compared to vehicle-treated Shunt lambs. ⺠Increases in BH4 enhanced NO generation in Shunt lambs.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Shruti Sharma, Xutong Sun, Sanjiv Kumar, Ruslan Rafikov, Angela Aramburo, Gokhan Kalkan, Jing Tian, Imran Rehmani, Suphin Kallarackal, Jeffrey R. Fineman, Stephen M. Black,