| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738042 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠The redox activity of APE1 is essential for mitochondrial function under oxidative stress. ⺠APE1 regulates the DNA-binding activity of NRF1 in a redox-dependent manner. ⺠The mitochondrial maintenance function of APE1 is NRF1-dependent.
Keywords
MMPEMSAMT-CO1peroxisome proliferator-activated receptor γ coactivator 1αAPE1tBHPtert-butylhydroperoxideNRF1TFAMPGC-1αMTSCOXDOXapurinic/apyrimidinic endonucleaseMitochondrial DNAROStranslocase of outer mitochondrial membranechromatin immunoprecipitationelectrophoretic mobility-shift assayOxidative stressmitochondrial targeting sequenceTOMMdoxycyclinemtDNAFree radicalselectron transport chaincytochrome c oxidaseMitochondrial functionETcMitochondrial membrane potentialCHiPReactive oxygen species
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Authors
Mengxia Li, Carlo Vascotto, Shangcheng Xu, Nan Dai, Yi Qing, Zhaoyang Zhong, Gianluca Tell, Dong Wang,