| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10738048 | Free Radical Biology and Medicine | 2012 | 9 Pages |
Abstract
⺠Maritime pine bark extract (Pycnogenol) was reported to inhibit NO production and inducible NO synthase. ⺠We found that the Pycnogenol metabolite M1 mediates these effects. ⺠Required effective M1 concentrations were higher than detected earlier in vivo. ⺠We observed a facilitated phloretin-sensitive uptake of M1 into cells. ⺠Intracellular M1 accumulation would explain in vivo bioactivity at nanomolar plasma levels.
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Authors
Klaus Uhlenhut, Petra Högger,